Survival Factors and Apoptosis

For this article, Tom Hollon interviewed Anne Brunet, a postdoctoral fellow in the division of neurosciences, Children's Hospital, Harvard Medical School. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. A. Brunet, A. Bonni, M.J. Zigmond, M.Z. Lin, P. Juo, L.S. Hu, M.J. Anderson, K.C. Arden, J. Blenis, M.E. Greenberg, "Akt promotes cell survival by phosphorylating and inhibiting a forkhea

Tom Hollon
Apr 1, 2001
For this article, Tom Hollon interviewed Anne Brunet, a postdoctoral fellow in the division of neurosciences, Children's Hospital, Harvard Medical School. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.


A. Brunet, A. Bonni, M.J. Zigmond, M.Z. Lin, P. Juo, L.S. Hu, M.J. Anderson, K.C. Arden, J. Blenis, M.E. Greenberg, "Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor," Cell 96: 857-68, March 19, 1999. (Cited in 239 papers)



Courtesy of Anne Brunet

Anne Brunet

Cell life depends on stringent repression of apoptosis, or programmed cell death. Repressing transcription of cell death genes is one way of preventing apoptosis. Another method relies on the presence of extracellular stimuli called survival factors that transduce signal pathways that keep apoptosis in check. Many growth factors and hormones...