Zhu et al., "MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM 1)," J Biol Chem, 282: 14328-36, 2007. (Cited in 76 papers)
A team led by Yin-Yuan Mo, a tumor cell biologist at the Southern Illinois University School of Medicine, measured global protein levels in mouse carcinoma tumors after blocking the activity of the microRNA-21 (mir-21), a cancer-associated small RNA that regulates gene expression. They found that mir-21 fuels tumor growth by silencing tumor suppressor gene 1 (TPM1), a gene that normally makes the muscle protein tropomyosin.
The paper makes an "important contribution" to understanding how microRNAs drive cancer by identifying the first target of mir-21, says Kenneth Kosik, a neuroscientist at the University of California, Santa Barbara, who also studies mir-21. The study's high throughput proteomic approach also provides a more reliable...
|Number of mir-21 targets identified|
|This study: 1|
|Cell Res, 2008: 2|
|Canc Res, 2008: 11|