Edited by: Paul Smaglik
Thomas R. Cech
Comments by Thomas R. Cech, professor of biochemistry, biophysics, and genetics at the University of Colorado Health Sciences Center, Boulder
This paper is "a derivative," laughs Thomas Cech. The "real breakthrough" paper that made it (and its companion, see below) possible came months earlier, but has received less citation attention than either of its successors. That earlier paper reported the purification of the telomerase enzyme's catalytic subunit--the first such subunit cloned.1 "That paper was the result of four years in the cold room by Joachim Lingner," Cech recalls, adding that the skill and diligence of the then-University of Colorado at...