Edited by: Ricki Lewis
D. Broccoli, J.W. Young, T. de Lange, "Telomerase activity in normal and malignant hematopoietic cells," Proceedings of the National Academy of Sciences, 92:9082-6, 1995. (Cited in 95 publications through June 1997)
Comments by Titia de Lange, Rockefeller University
UNEXPECTED FINDING: Titia de Lange's lab at Rockefeller University used a sensitive assay to detect telomerase activity in noncancerous cells.
The telomeres, or chromosome tips, of human somatic cells shrink with each cell division. In germline cells such as sperm and in malignant cells, chromosome length is maintained by telomerase, an enzyme that...