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The Delicate Balancing Act

For this article, Laura DeFrancesco interviewed Lorenz Hofbauer, head of the Molecular Bone Biology Laboratory at Philipps University, Marburg, Germany; Colin Dunstan, senior research scientist, Amgen Inc., in Thousand Oaks, Calif., and Sundeep Khosla, professor of medicine, Mayo Medical School. Data from the Web of Science show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. L.C. Hofbauer, S. Khosla, C.R. Dunstan, et al., "The roles of oste

Laura Defrancesco
For this article, Laura DeFrancesco interviewed Lorenz Hofbauer, head of the Molecular Bone Biology Laboratory at Philipps University, Marburg, Germany; Colin Dunstan, senior research scientist, Amgen Inc., in Thousand Oaks, Calif., and Sundeep Khosla, professor of medicine, Mayo Medical School. Data from the Web of Science show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

L.C. Hofbauer, S. Khosla, C.R. Dunstan, et al., "The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption," Journal of Bone and Mineral Research,15:2-12, January 2000. (Cited in 102 papers)


Osteoblasts and osteoclasts do a delicate dance to keep bone formation and bone resorption, respectively, in balance. Upset this equilibrium, and at one extreme, osteoporosis develops, a common malady that decreases bone mass, while at the other extreme, osteopetrosis occurs, a rare but...

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