A.L. Cox, J. Skipper, Y. Chen, R.A. Henderson, T.L. Darrow, J. Shabanowitz, V.H. Engelhard, D.F. Hunt, C.L. Slingluff, "Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines," Science, 264:716-9, 1994. (Cited in more than 60 articles through September 1995)
Comments by Victor Engelhard, University of Virginia, Charlottesville
The importance of this paper, according to Victor Engelhard, a professor of microbiology at the University of Virginia, is that "it was one of the first conclusive reports describing a specific tumor antigen to be recognized by cytotoxic T cells in humans.
PINPOINTING PEPTIDES: Victor Engelhard's team identified a tumor antigen specific to melanoma cells.
"Historically, immunologists have been alternately excited and despondent with respect to harnessing the immune system against cancer," he explains. "The area got its most recent jump start around the mid-1980s, when [Steven] Rosenberg showed that lymphocytes isolated from excised human tumors...