Tumor Suppression

For this article, Steve Bunk interviewed Ronald A. DePinho, professor of genetics, Dana Farber Cancer Institute, Harvard Medical School. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. J. Pomerantz, N. Schreiber-Agus, N.J. Liégeois, A. Silverman, L. Alland, L. Chin, J. Potes, K. Chen, I. Orlow, H-W. Lee, C. Cordon-Cardo, R.A. DePinho, "The INK4a tumor suppressor gene product, p19ARF,

Steve Bunk
Sep 3, 2000

For this article, Steve Bunk interviewed Ronald A. DePinho, professor of genetics, Dana Farber Cancer Institute, Harvard Medical School. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

J. Pomerantz, N. Schreiber-Agus, N.J. Liégeois, A. Silverman, L. Alland, L. Chin, J. Potes, K. Chen, I. Orlow, H-W. Lee, C. Cordon-Cardo, R.A. DePinho, "The INK4a tumor suppressor gene product, p19ARF, interacts with MDM2 and neutralizes MDM2's inhibition of p53," Cell, 92:713-23, March 20, 1998. (Cited in more than 265 papers since publication)

All tumor suppressor pathways may not lead to their Rome, but for two pathways, a critical crossroads has been found on chromosome 9. This locus is called INK4a/ARF (inhibitor of cyclin-dependent kinase 4a/alternative reading frame). It encodes two proteins. One of them, p16INK4a, functions in...