M.F. Fraga, et al. ?Epigenetic differences arise during the lifetime of monozygotic twins.? Proc Natl Acad Sci, 102:10413?4, 2005. (cited in 91 papers)
Investigating epigenetic profiles of 80 sets of identical twins, ages 3 to 74, Manel Esteller of the Spanish National Cancer Center in Madrid and his colleagues revealed how lifestyle and age can impact phenotype. Unsurprisingly, older twin pairs differed more in things like DNA methylation and histone acetylation than younger twins. Greater lifestyle dissimilarities between twins correlated with epigenetic variability, and gene expression microarrays confirmed that epigenetic differences correspond with increased phenotypic disparities.
?We are now mapping twins with different penetrance for a particular disease, such as diabetes or autoimmune disease,? Esteller says. ?By comparing the epigenomes of both twins, we can isolate genes that contribute to the development of these diseases.?...
|Female twins: 50 pairs|
|Male twins: 30 pairs|
|Mean age: 30.6 pairs|
|Twin pairs with significant differences in DNA methylation and histone acetylation profiles: 35%|