Edited by: Stephen P. Hoffert
B.J. Doranz, J. Rucker, Y. Yi, R.J. Smyth, M. Samson, S.C. Peiper, M. Parmentier, R.G. Collman, R.W. Doms, "A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors," Cell, 85:1149-58, 1996. (Cited in more than 230 publications through November 1997)
Comments by Benjamin J. Doranz, Department of Pathology and Laboratory Medicine, University of Pennsylvania
While the cell surface protein receptor CD4 has been identified as the primary receptor for HIV, additional molecules, called coreceptors, are required for the virus to enter and infect a cell. Studies over the past decade have demonstrated that these coreceptors also determine the types of viral strains responsible for person-to-person transmission and the rate of onset of AIDS. For example, cells with the receptor CD4 typically are the target of T-tropic but not M-tropic HIV. T-tropic viruses emerge gradually...