Edited by: Karen Young Kreeger
E.M. Connor, R.S. Sperling, R. Gelber, P. Kiselev, G. Scott, M.J. O'Sullivan, R. VanDyke, M. Bey, W. Shearer, R.L. Jacobson, E. Jimenez, E. O'Neill, B. Bazin, J.-F. Delfraissy, M. Culnane, R. Coombs, M. Elkins, J. Moye, P. Stratton, J. Balsley, "Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment," New England Journal of Medicine, 331:1173-80, 1994. (Cited in nearly 130 publications through June 1996)

Comments by Edward M. Connor, MedImmune Inc., Gaithersburg, Md.

Mother-infant transmission accounts for more than 90 percent of all HIV infections in young children, according to the Joint United Nations Programme on HIV/AIDS (UNAIDS), a global AIDS research effort. About 3 million children worldwide have become infected in this way. Most infection occurs in the third trimester of pregnancy or during labor, delivery, and breast-feeding.

'HUGE IMPACT': Maternal-infant HIV transmission was reduced by...

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