P. Vallance, J. Collier, S. Moncada, "Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man," Lancet, 2:997-1000, 1989.

Joe Collier (St. George's Hospital Medical School, London): "The Clinical Pharmacology Unit at St. George's Hospital Medical School has a tradition of seeking to understand the local pharmacology of human peripheral vasculature both in health and in disease. Much of the early work on the peripheral actions (venous and arterial) of, for example, b-blockers, calcium antagonists, prostaglandins, and ACE inhibitors came from the unit, and so it was natural that we would become immersed in the EDRF [endothelium-derived relaxing

factor] story. Initial studies involving endothelial denudation of the dorsal hand veins, indicated that veins, at least, were capable of releasing nitric oxide. The advent of the NO-synthetase blocker L-NMMA allowed us to look at this effect in arteries, but, in this instance, by means of `pharmacological' denudation. We believe...

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