D.A. Cheresh, J.W. Smith, H.M. Cooper, V. Quaranta, "A novel vitronectin receptor integrin (Aváx) is responsible for distinct adhesive properties of carcinoma cells," Cell, 57, 59-69, 7 April 1989.

David A. Cheresh (Research Institute of Scripps Clinic, La Jolla, Calif.): "Cellular adhesion events are required for normal embryonic development, wound healing, thrombosis, and immune function. However, during disease processes (such as cancer, microbial infection, and inflammation), some of the same cellular adhesion mechanisms contribute to severe, and often fatal, consequences. During the last few years it has become clear that the molecular basis of these cellular adhesion mechanisms is determined to a large extent by a family of proteins termed integrins. The integrins are cell surface heterodimers that function in a cation-dependent manner.

"Our study was the first to demonstrate that within the integrin family of cell adhesion receptors a given A subunit (Av) could associate with more...

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