J. Minshull, J.J Blow, T. Hunt, "Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis," Cell, 56, 947-56, 24 March 1989.
Jeremy Minshull (University of Cambridge, England): "The last two years have seen dramatic progress in understanding the control of the cell cycle, in particular the control of mitosis. The discovery of cyclins played an important part in bringing together various threads of evidence from studies of frog oocyte maturation and yeast genetics. Cyclins, combine with the cell-cycle protein p34cdc2 to form the mitotic kinase.
"This paper was the first to show that cyclins were present in a vertebrate and were not some specialized curiosity found only in sea urchins and clam embryos. Second, it provided the first direct evidence that cyclin synthesis could explain the long-known protein synthesis requirement for entry into mitosis. We used oligonucleotides and RNAse H to destroy...
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