D.W. Choi, "Glutamate neurotoxicity and diseases of the nervous system," Neuron, 1, 623-34, October 1988.

Dennis Choi (Stanford University, Calif.): "I think that citation of this review article reflects the high level of interest and research activity now extant in the area of excitatory amino acid-induced neuronal injury. It is not so much that the paper is a `hot paper' as that glutamate neurotoxicity is a `hot field.' Although it was more than 20 years ago that John Olney [The Scientist, Feb. 5, 1990, page 1] found that excess exposure to glutamate could kill brain neurons, it has been just in the last few years that strong evidence has appeared, linking glutamate neurotoxicity with the pathogenesis of neuronal loss after acute insults. Further enthusiasm has been generated by speculations that glutamate receptor-mediated neurotoxicity may also be involved in chronic neurodegenerative diseases. A key to this surge...

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