L.A. Lasky, M.S. Singer, T.A. Yednock, D. Dowbenko, et al., "Cloning of a lymphocyte homing receptor reveals a lectin domain," Cell, 56, 1045-55, 24 March 1989.

Lawrence A. Lasky (Genentech Inc., South San Francisco): "The trafficking of leukocytic cells to various regions of the vascular system during normal and inflammatory immune responses involves a number of cell surface adhesion molecules. One of the more interesting of these molecules is the homing receptor, so named because it allows white cells to home in on peripheral lymph nodes, and perhaps, sites of inflammation. Previous work demonstrated that this receptor may contain a sugar recognition site involved with adhesion. The molecular cloning of the murine homing receptor, reported in this paper, demonstrated that this adhesion receptor also contains a carbohydrate recognition, or lectin, motif. This exciting result showed that this receptor appears to direct leukocytes to peripheral lymph nodes by recognition...

Interested in reading more?

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?