Ovary stained for MUM1L1 (left), testes stained for unknown protein encoded by C2ORF57 (right)HUMAN PROTEIN ATLAS Researchers in Sweden have completed an exhaustive map of protein and RNA expression across 32 human tissues and organs. Mathias Uhlén of the Royal Institute of Technology in Stockholm and his colleagues report their findings today (January 22) in Science. The Human Protein Atlas joins the Human Proteome Map, among other publicly available proteomics resources.
The team generated this latest catalog of the human proteome using more than 24,000 polyclonal antibodies to visualize the locations of each of 16,975 unique proteins, corresponding to 85 percent of all genes in the genome. The result is more than 13 million antibody-stained immunohistochemistry images. To add a quantitative layer, the team supplemented its spatial protein mapping with quantitative RNA-sequencing data for 32 tissues types. Users of the Human Protein Atlas can search for and download information for a protein or gene or a subset of the proteomic data.
“The big strength of this [database] is the ease of navigation,” Anne-Claude Gingras, a proteomics researcher at the Lunenfeld-Tanenbaum Research Institute in Toronto, Canada, who was not involved in the work, wrote in an e-mail ...
