Menu

Image of the Day: Cellular Tracks

To study the fate of stem cells in developing chick embryos, researchers trace their steps over time.

Jan 21, 2019
Carolyn Wilke
The locations of a developing chick’s endoderm cells over the course of 16 hours are marked by colored trail, purple at the start of the time lapse and white at the end.
NANDAN NERURKAR/COLUMBIA ENGINEERING

Scientists are tracking stem cells on their way to becoming tissues and organs to learn how genes and molecules direct the process and which forces are at play.

They looked at one group of stem cells, called endoderm cells, in developing chicks. These stem cells begin as a flat sheet on the embryo’s surface and move toward its center as the bird develops. En route, they form the hollow gut tube that eventually becomes the lining of the respiratory and gastrointestinal tracts. 

Focusing on the hindgut, which gives rise to parts of the small and large intestines and the colon, the scientists tracked endoderm cells’ motion over time. The study, published in Nature on January 16, reveals that the hindgut forms in response to a mass migration of endoderm cells triggered by chemical signals and physical forces. 

N.L. Nerurkar et al., “Molecular control of macroscopic forces drives formation of the vertebrate hindgut,” Nature, doi:10.1038/s41586-018-0865-9, 2019.

February 2019

Big Storms Brewing

Can forests weather more major hurricanes?

Marketplace

Sponsored Product Updates

Bio-Rad Showcases New Automation Features of its ZE5 Cell Analyzer at SLAS 2019
Bio-Rad Showcases New Automation Features of its ZE5 Cell Analyzer at SLAS 2019
Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb) today showcases new automation features of its ZE5 Cell Analyzer during the Society for Laboratory Automation and Screening 2019 International Conference and Exhibition (SLAS) in Washington, D.C., February 2–6. These capabilities enable the ZE5 to be used for high-throughput flow cytometry in biomarker discovery and phenotypic screening.
Andrew Alliance and Sartorius Collaborate to Provide Software-Connected Pipettes for Life Science Research
Andrew Alliance and Sartorius Collaborate to Provide Software-Connected Pipettes for Life Science Research
Researchers to benefit from an innovative software-connected pipetting system, bringing improved reproducibility and traceability of experiments to life-science laboratories.
Corning Life Sciences to Feature 3D Cell Culture Technologies at SLAS 2019
Corning Life Sciences to Feature 3D Cell Culture Technologies at SLAS 2019
Corning Incorporated (NYSE: GLW) will showcase advanced 3D cell culture technologies and workflow solutions for spheroids, organoids, tissue models, and applications including ADME/toxicology at the Society for Laboratory Automation and Screening (SLAS) conference, Feb. 2-6 in Washington, D.C.
Corning Introduces New 1536-well Spheroid Microplate
Corning Introduces New 1536-well Spheroid Microplate
High-throughput spheroid microplate benefits cancer research, drug screening