lymph lymphatics mouse embryo polycystic kidney disease pkd
kidney lymphatics

Image of the Day: Kidney Lymphatics

Single-cell-resolution imaging offers a glimpse into lymphatic vessel formation in the mouse embryo.

Amy Schleunes
Amy Schleunes

A former intern at The Scientist, Amy studied neurobiology at Cornell University and later earned her MFA in creative writing from the University of Iowa. She is a Los...

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Jan 15, 2020

A study published in eLife last month used three-dimensional imaging in mouse embryos to investigate the role of the lymphatic system in both normal and abnormal renal development.

Imaging revealed that lymphatic structures emerge roughly halfway through the kidney’s development, with rapid growth at the point when the kidney likely starts to filter blood in the embryo.

A mouse model of polycystic kidney disease (PKD) that the authors examined experienced a number of abnormalities during embryonic development, including cyst formation near lymphatic vessels in the outer portion of the kidney, a stunted lymphatic network, reduced lymph vessel diameter, and reduced lymphatic volume.

Amy Schleunes is an intern at The Scientist. Email her at