Menu

Image of the Day: Parasite Stopped in Its Tracks

Suppression of a signaling pathway in Toxoplasma gondii prevents the parasite from replicating in host cells.

Sep 26, 2018
Iris Kulbatski

ABOVE: Walter and Eliza Hall Institute researchers have discovered a way to halt the invasion of the Toxoplasma gondii parasite into cells.
WALTER AND ELIZA HALL INSTITUTE, AUSTRALIA

Researchers from the Walter and Eliza Hall Institute in Australia have discovered a novel approach to preventing Toxoplasma gondii infection from taking hold. By disabling protein kinase A (PKA), which normally activates parasite replication, the team initiated a mechanism of T. gondii egress from host cells. Unable to replicate, the parasite cannot flourish.

Commonly found in raw meat and cat feces, T. gondii causes a disease called toxoplasmosis, which presents with fever and muscle aches, and poses a risk to pregnant women in particular.  The research, published this month (September 12) in PLOS Biology, provides potential targets for a vaccine against the pathogen.

A.D. Uboldi et al., “Protein kinase A negatively regulates Ca2+ signalling in Toxoplasma gondii,” PLOS Biologydoi:10.1371/journal.pbio.2005642, 2018.

October 2018

Bright Lights, Big Problems

Scientists are exploring the ecological damage caused by artificially lit night skies

Marketplace

Sponsored Product Updates

Neural Cell Culturing Guide

Neural Cell Culturing Guide

Download this guide from R&D Systems to learn the fundamental techniques and protocols for successfully isolating, culturing, and expanding specific cell types from the rodent central and peripheral nervous systems!

Immunophenotyping Extracellular Vesicles Using Amnis® Technology

Immunophenotyping Extracellular Vesicles Using Amnis® Technology

Download this application note to learn how the Amnis® time delay integration (TDI) image capturing system facilitates high-throughput flow cytometry with high sensitivity to submicron particles!

Improving Accuracy in Serial Dilutions Using the Electronic Pipette

Improving Accuracy in Serial Dilutions Using the Electronic Pipette

Electronic pipettes provide more accurate sample concentrations, reduced error propagation, and improved ergonomics. Download this application note from Sartorius to learn more!

Benefits of Electronic Pipette Use for Pipetting PCR Master Mix

Benefits of Electronic Pipette Use for Pipetting PCR Master Mix

Download this application note from Sartorius to explore how electronic pipettes can help ensure reproducible and reliable results when performing PCR-based assays.