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Image of the Day: Pipelines

Collagen tunnels through mouse lymph nodes ferry antibodies into the bloodstream.

Nov 19, 2018
Shawna Williams

ABOVE: A fluorescence micrograph showing antibody-secreting mouse lymphocytes in white and conduits made of collagen in green
© G. THIERRY

Tunnels made of collagen run through lymph nodes, drawing infection-fighting antibodies away from the cells that secrete them and into the bloodstream, a new study in mice reports. The results, which appeared November 14 in the Journal of Experimental Medicine, give insight into how lymph nodes release antibodies.

G.R. Thierry et al., “The conduit system exports locally secreted IgM from lymph nodes,” J Exp Med, doi:10.1084/jem.20180344, 2018.

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