Image of the Day: Transgenic Axolotl

Lineage tracing reveals how cells help the salamanders regrow chopped-off limbs.

Kerry Grens
Oct 3, 2018
The regrown limb of an axolotl bears various cell types labeled by fluorescent proteins. Scale bar is 300 micrometers.

Axolotls (Ambystoma mexicanum) have the remarkable ability to regrow missing body parts. In a study reported in Science last week (September 27), investigators traced cells that form the regenerative tissue once a limb is amputated, finding that they de-differentiate themselves during the repair process to a multipotent state to become like a limb bud typical of embryonic development.