Image of the Day: Arrhythmogenic Cardiomyopathy

Scientists identify a potential biomarker for predicting the progression of a deadly cardiac disease.

Amy Schleunes
Amy Schleunes

A former intern at The Scientist, Amy studied neurobiology at Cornell University and later earned her MFA in creative writing from the University of Iowa. She is a Los...

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Feb 24, 2020
Heart tissue from an arrhythmogenic cardiomyopathy patient features characteristic fatty deposits in white.
J.-P. Song et al., Science Translational Medicine, 2020

Ametabolic biomarker in an inherited heart disorder called arrhythmogenic cardiomyopathy could predict the progression of disease, which in some cases has no detectable symptoms and can result in sudden death, according to a study published on February 12 in Science Translational Medicine.

Researchers identified elevated levels of β-hydroxybutyrate, a ketone body that is the product of fatty acid oxidation, in the heart tissue of patients with arrhythmogenic cardiomyopathy, as well as in plasma samples from both patients and their relatives suspected of having the disease, according to a press release. A mouse model also confirmed elevated levels of the same biomarker. 

J.-P. Song et al., “Elevated plasma β-hydroxybutyrate predicts adverse outcomes and disease progression in patients with arrhythmogenic cardiomyopathy,” Science Translational Medicinedoi:10.1126/scitranslmed.aay8329, 2020.

Amy Schleunes is an intern at The Scientist. Email her at