Menu

Image of the Day: DNA Knitter

Researchers show how condensin complexes organize DNA in real time.

Feb 27, 2018
The Scientist Staff, The Scientist Staff

A condensin protein (red) binds DNA (green) and extrudes a DNA loop.CEES DEKKER LAB, KAVLI INSTITUTE OF NANOSCIENCE

Researchers at Kavli Institute of Delft University and EMBL Heidelberg have filmed a protein apparatus manipulating the shape of DNA. In the video, a condensin complex remains bound at the stem of a piece of DNA, which it pulls into a loop. This mechanism is vital to the cell’s ability to neatly package meters-long strands of DNA base pairs into compact chromosomes only a few micrometers in size.

Mahipal Ganji, a biophysicist at Delft University, and colleagues reported in Science on February 22 that they first tethered two ends of a piece of DNA to a surface and observed the condensin complex as it moved along the strand, pulling DNA into a loop at a rate of about 0.6 kilobase pairs per second.

M. Ganji et al., “Real-time imaging of DNA loop extrusion by condensin,” Science, doi:10.1126/science.aar7831, 2018.

April 2019

Will Car T Cells Smash Tumors?

New trials take the therapy beyond the blood

Marketplace

Sponsored Product Updates

Myth Busting: The Best Way to Use Pure Water in the Lab
Myth Busting: The Best Way to Use Pure Water in the Lab
Download this white paper from ELGA LabWater to learn about the role of pure water in the laboratory and the advantages of in-house water purification!
Shimadzu's New Nexera UHPLC Series with AI and IoT Enhancements Sets Industry Standard for Intelligence, Efficiency and Design
Shimadzu's New Nexera UHPLC Series with AI and IoT Enhancements Sets Industry Standard for Intelligence, Efficiency and Design
Shimadzu Corporation announces the release of the Nexera Ultra High-Performance Liquid Chromatograph series, incorporating artificial intelligence as Analytical Intelligence, allowing systems to detect and resolve issues automatically. The Nexera series makes lab management simple by integrating IoT and device networking, enabling users to easily review instrument status, optimize resource allocation, and achieve higher throughput.
IDT lowers genomic barriers with powerful rhAmpSeq™ targeted sequencing system
IDT lowers genomic barriers with powerful rhAmpSeq™ targeted sequencing system
Increasing accuracy and reducing cost barriers, IDT’s innovative system delivers simple and cost-effective amplicon sequencing
Bio-Rad Introduces Isotype-Specific Secondary Antibodies
Bio-Rad Introduces Isotype-Specific Secondary Antibodies
Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb), a global leader of life science research and clinical diagnostic products, today announced the launch of its isotype-specific secondary antibodies. This new range of recombinant monoclonal antibodies, directed against the three main mouse isotypes: IgG1, IgG2a, and IgG2b, offer improved signal detection and specificity in imaging, ELISA, flow cytometry, and western blotting.