Menu

Image of the Day: Flushing the Gut

In response to a bacterial infection, an immune signal in mice's guts triggers a molecular cascade that promotes diarrhea, which, researchers demonstrate, is important for ridding them of the bacteria.  

Jun 19, 2017
The Scientist Staff

An immunofluorescence microscopy image depicts the intestinal lumen of a mouse lacking claudin-2, a diarrhea-inducing tight junction protein. In these deficient mice, C. rodentium bacteria (red) infiltrate the intestines. DNA stained in blue; F-actin (denoting cells' external-facing surfaces) in green.

TURNER LABORATORY AT BRIGHAM AND WOMEN’S HOSPITAL

           Scientists investigating the functional role of diarrhea found that bacterial pathogens stimulate the immune signaling protein IL-22, which increases claudin-2 expression and facilitates the outflow of water and subsequently, diarrhea. According to a news release, this “play[s] a critical role in pathogen clearance in the early stages of infection.”

See P.-Y. Tsai et al., “IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance,” Cell Host & Microbe, doi:10.1016/j.chom.2017.05.009, 2017.

July/August 2019

On Target

Researchers strive to make individualized medicine a reality

Marketplace

Sponsored Product Updates

DNASTAR® announced the release of Lasergene 16 Software
DNASTAR® announced the release of Lasergene 16 Software
DNASTAR® announced the release of Lasergene 16 today, which includes a broad range of improvements in for analysis of DNA, RNA and protein sequence data, as well as new advancements for predicting and analyzing protein structures. 
Arbor Biosciences Partners with Curio Genomics for Analysis of IWGSC Wheat Exome
Arbor Biosciences Partners with Curio Genomics for Analysis of IWGSC Wheat Exome
Arbor Biosciences, a division of Chiral Technologies, Inc and worldwide leader in next generation sequencing (NGS) target enrichment, announces a partnership with Curio Genomics for bioinformatics analysis of the wheat genome.
IDT and Washington University join forces to increase access to the latest NGS technologies
IDT and Washington University join forces to increase access to the latest NGS technologies
As part of its commitment to advocate for the genomics age, Integrated DNA Technologies (IDT) aims to lower the barriers to access the latest NGS technologies.
Bio-Rad Launches Bio-Plex Pro Human Immunotherapy Panel 20-plex Multiplex Assay, a targeted tool for researching signaling networks in Immunotherapy Research
Bio-Rad Launches Bio-Plex Pro Human Immunotherapy Panel 20-plex Multiplex Assay, a targeted tool for researching signaling networks in Immunotherapy Research
Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb) July 15, 2019 announced the launch of its Bio-Plex Pro Human Immunotherapy Panel 20-plex, a multiplex immunoassay that offers a targeted approach for Immunotherapy Research.