Menu

Image of the Day: Glowing Larva

Researchers identified a gene in mosquitoes that moderates their susceptibility to malaria parasite infection. 

Mar 9, 2018
The Scientist Staff, The Scientist Staff

A. gambiae transgenic larva Y. DONG ET AL.Researchers reported yesterday (March 8) in PLOS Pathogens that inactivating the gene FREP1 reduced mosquitoes’ (Anopheles gambiae) susceptibility to Plasmodium, the parasite that causes malaria in humans.

When an A. gambiae mosquito consumes a Plasmodium in a blood meal, the parasite goes through a complex infection cycle as it travels to its host’s salivary gland, from where it infects humans. The Plasmodium’s ability to complete this cycle relies on the activity of several of the mosquito’s proteins. Using CRISPR-Cas9, the team from Johns Hopkins University inactivated the gene encoding fibrinogen-related protein 1 (FREP1), a target they had previously identified as being involved in the infection process. They found that knocking out the gene suppressed Plasmodium infection in mosquitoes. In their paper, the researchers write that the technique is “a potentially powerful approach” to generating infection-resistant mosquitoes.

Y. Dong et al., “CRISPR/Cas9-mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection,” PLOS Pathogens, doi:10.1371/journal.ppat.1006898, 2018.

February 2019

Big Storms Brewing

Can forests weather more major hurricanes?

Marketplace

Sponsored Product Updates

Bio-Rad Showcases New Automation Features of its ZE5 Cell Analyzer at SLAS 2019
Bio-Rad Showcases New Automation Features of its ZE5 Cell Analyzer at SLAS 2019
Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb) today showcases new automation features of its ZE5 Cell Analyzer during the Society for Laboratory Automation and Screening 2019 International Conference and Exhibition (SLAS) in Washington, D.C., February 2–6. These capabilities enable the ZE5 to be used for high-throughput flow cytometry in biomarker discovery and phenotypic screening.
Andrew Alliance and Sartorius Collaborate to Provide Software-Connected Pipettes for Life Science Research
Andrew Alliance and Sartorius Collaborate to Provide Software-Connected Pipettes for Life Science Research
Researchers to benefit from an innovative software-connected pipetting system, bringing improved reproducibility and traceability of experiments to life-science laboratories.
Corning Life Sciences to Feature 3D Cell Culture Technologies at SLAS 2019
Corning Life Sciences to Feature 3D Cell Culture Technologies at SLAS 2019
Corning Incorporated (NYSE: GLW) will showcase advanced 3D cell culture technologies and workflow solutions for spheroids, organoids, tissue models, and applications including ADME/toxicology at the Society for Laboratory Automation and Screening (SLAS) conference, Feb. 2-6 in Washington, D.C.
Corning Introduces New 1536-well Spheroid Microplate
Corning Introduces New 1536-well Spheroid Microplate
High-throughput spheroid microplate benefits cancer research, drug screening