Menu

Image of the Day: Itch to Scratch

Blocking a key receptor in itch-detecting neurons could quell chronic conditions.

Nicoletta Lanese
Jul 17, 2019

ABOVE: Mouse sensory nerves involved in itch detection (green) clustered among those that detect pain, temperature and other stimuli (magenta).
SOLINKSKI ET AL., 2019

In a new study, scientists screened more than 86,000 small molecules to spot a few capable of blocking a critical receptor for itchy sensations, Npr1. The receptor is expressed in both human and mouse sensory neurons alongside the spinal cord, and may contribute to chronic conditions like eczema and psoriasis, the researchers reported July 10 in Science Translational Medicine. We wanted to show that by pharmacologically blocking the target receptor, the approach could be successful in finding a drug to treat chronic itch,” says study coauthor James Inglese of NCATS in a press release. The authors plan to investigate exactly how their candidate compounds block Npr1, and eventually, whether they can be modified for clinical use.

H. Solinski, et al., “Inhibition of natriuretic peptide receptor 1 reduces itch in mice,” Sci Transl Med11:eaav5464, 2019.

Nicoletta Lanese is an intern at The Scientist. Email her at nlanese@the-scientist.com.

June 2020

An Infant's Bounty

Babies amass microbes that can pave the way to a healthy life

Marketplace

Sponsored Product Updates

Imaging Multicolor Western Blots
Introducing The FluorChem R Imaging System
In-House Water Compared to Bottled HPLC-Grade Water
Download this application note to learn how in-house water is an effective option as an HPLC mobile phase!
Considerations to Ensure Optimal Isolation of Single Cells
This review article focuses on the upstream considerations for isolation of individual cells to yield optimal results in single cell applications.
Abingdon Health announces its latest expansion and additional manufacturing capacity
Abingdon Health is pleased to announce further expansion at its York headquarters in the UK, following further investment in state-of-the-art lateral flow automation.