Image of the Day: Molecular Coalition

Cancer-fighting microRNAs joined together with folate prefer to enter folate receptor-expressing tumor cells over normal cells in mice.

The Scientist Staff
Aug 7, 2017

The right lobe of a mouse lung, labeled with a hematoxylin and eosin (h&E) stain (left) and fluorescence imaging (right). A folate receptor ligand attached to a dye sticks to mouse lung tumors (1,3) but not normal tissue (2).ORELLANA ET AL., SCI TRANS MED, 9:EAAM9327, 2017 Scientists demonstrate that a tumor-attacking miRNA joined with folate can precisely target cancer cells expressing folate receptors, suppress their gene expression, and slow them down. 

See E.A. Orellana et al., “FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer,” Sci Trans Med, 9:eaam9327, 2017.

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Image of the Day: Molecular Coalition

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