Image of the Day: New Growth

Injection of a hydrogel that mechanically resembles a blood clot promotes the growth of new blood vessels in mice.

Chia-Yi Hou
Apr 12, 2019
New growth of endothelium (green), which will form new blood vessels in a section of muscle in mice. Nuclei are stained blue.

Researchers stimulated new blood vessel growth in mice by implanting a hydrogel that has a similar stiffness to a blood clot. The result links mechanical cues in the microenvironment to the maturation and stabilization of blood vessels.

A. Forget et al., “Mechanically defined microenvironment promotes stabilization of microvasculature, which correlates with the enrichment of a novel piezo-1+ population of circulating CD11b+/CD115+ monocytes,” Advanced Materials, doi:10.1002/adma.201808050, 2019.