THE ROCKEFELLER UNIVERSITY
In a study in Nature last week (March 15), researchers report that they have created a 3-D model of the nuclear pore complex in Saccharomyces cerevisiae yeast cells. The architecture of the gateway, which spans the nuclear envelope and allows molecules to enter and leave a cell’s nucleus, shares engineering principles found in large-scale construction projects.
“It reminds us of a suspension bridge, in which a combination of sturdy and flexible parts produce a stress-resilient structure,” says coauthor Michael Rout, a biochemist at the Rockefeller University, in a statement. Rout began mapping the complex more than 20 years ago with his colleague Brian Chait, a biochemist at Rockefeller.
The nuclear pore complex comprises 552 proteins, called...
S.J. Kim et al., “Integrative structure and functional anatomy of a nuclear pore complex,” Nature, doi:10.1038/nature26003, 2018.