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Scientists demonstrate that just the right amount of inflammation after an injury to a mouse’s olfactory epithelium is key for regenerating cells important for smell.

Sep 5, 2017
The Scientist Staff

Olfactory basal cells (green) start to regenerate three days following an injury in a normal mouse (image with larger labeled region), while tissue from a mouse engineered with a genetically hindered NF-κB pathway illustrates that without these immune signals, these cells don’t grow back (image with smaller labeled region).ANDREW LANE LAB See M. Chen et al., “Acute inflammation regulates neuroregeneration through the NF-κB pathway in olfactory epithelium,”PNASdoi:10.1073/pnas.1620664114, 2017.