“In terms of disease progression, heart failure is the end stage,” says senior author Chad Grueterin a news release. “Our study suggests that the transition, or ‘switch,’ from a stressed, enlarged heart to a failing heart is key. Looking ahead, hopefully we’ll be able to test whether a drug can block that switch from occurring.”
See D.D. Hall et al., “Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure,” JCI Insight, 2:e92476, 2017.