Diethylhexyl phthalate, a widely used plasticizer associated with reproductive harm in mammals, leads to defects during meiosis in roundworms (Caenorhabditis elegans), researchers report in a study published on January 9 in PLOS Genetics.
Using a previously developed technology that causes worms to glow green when they display reproductive abnormalities, the researchers uncovered several aberrations during the process of meiosis in female worms, including double-stranded DNA breaks that weren’t properly repaired, altered chromosome morphology, eggs with the wrong number of chromosomes, and impaired embryogenesis, according to a press release.
“These are completely new findings and hopefully will shed some light as to how this phthalate...
L. Cuenca et al., “Environmentally-relevant exposure to diethylhexyl phthalate (DEHP) alters regulation of double-strand break formation and crossover designation leading to germline dysfunction in Caenorhabditis elegans,” doi:10.1371/journal.pgen.1008529, 2020.
Amy Schleunes is an intern at The Scientist. Email her at email@example.com.