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Image of the Day: Synchronized Neurons

Memory formation in mice involves coordinated activity at the cellular level that likely leads to new circuits in the brain.

Amy Schleunes
Feb 14, 2020
Calcium dynamics in the mouse hippocampus show silent neurons (in blue) alongside highly active neurons (in yellow and red) that synchronize their activity in response to foot-shock conditioning.
UNIVERSITY OF NEW HAMPSHIRE

Hippocampal neuron activity coalesces into a coordinated firing pattern as memories form in the mouse brain, according to a study published on January 15 in The FASEB Journal. The authors used fear conditioning to produce “activity synchronization” in neurons that was correlated with freezing behavior, a process they believe “is critical for trace memory formation and retrieval,” they write in their study.

“There are tens of millions of neurons in the hippocampus but only a small fraction of them are involved in this learning process,” says University of New Hampshire neurobiologist and coauthor Xuanmao Chen in a press release. “Before engaging in Pavlovian conditioning, these neurons are highly active, almost chaotic, without much coordination with each other, but during memory formation they change their pattern from random to synchronized, likely forging new connecting circuits in the brain to bridge two unrelated events.”

Y. Zhou et al., “Induction of activity synchronization among primed hippocampal neurons out of random dynamics is key for trace memory formation and retrieval,” The FASEB Journal, doi:10.1096/fj.201902274R, 2020.

Amy Schleunes is an intern at The Scientist. Email her at aschleunes@the-scientist.com.

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