Edited by: Eugene Russo

T CELL STARTER: Harvard's Michael Grusby believes that research on Stat pathways will lead to a better understanding of T cell differentiation.
M.H. Kaplan, U. Schindler, S.T. Smiley, M.J. Grusby, "Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells," Immunity, 4:313-9, 1996. (Cited in more than 75 publications as of February 1998)

Comments by Michael J. Grusby, Department of Immunology and Infectious Diseases, Harvard School of Public Health

Sometimes good cells turn bad. When produced at the wrong time, T helper cells, which are meant to fight off harmful antigens, can end up attacking the molecules, cells, and tissues that they're suppose to be defending, thereby causing autoimmune diseases. Potential therapies for such disorders may entail the manipulation of the cell pathways that lead to T helper cell differentiation. Scientists have attempted to do so by identifying the...

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