Edited by: Karen Young Kreeger

MAKING A MIGHTY MOUSE: Yale's Richard Flavell and coworkers developed a CD40 ligand-less knockout mouse.
J.C. Xu, T.M. Foy, J.D. Laman, E.A. Elliott, J.J. Dunn, T.J. Waldschmidt, J. ore, R.J. Noelle, R.A. Flavell, "Mice deficient for the CD40 ligand," Immunity, 1:423-31, 1994 (Cited in more than 80 publications as of August 1996)

Comments by Richard A. Flavell, Howard Hughes Medical Institute, Yale University School of Medicine

To more closely investigate the role of cell surface receptors in the human immune response, scientists at Yale University genetically engineered a knockout mouse without the gene for CD40L, a ligand molecule that binds to CD40. They designed these mice in collaboration with investigators at Dartmouth Medical School and the University of Iowa Medical School.

"The molecule CD40 is found on many antigen-presenting cells, although it was initially thought to be only on B cells," says...

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