A.L. Burkhardt, M. Brunswick, J.B. Bolen, J.J. Mond, "Anti- immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases," Proceedings of the National Academy of Sciences, 88:741-14, 1991.
Joseph Bolen (Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, N.J.): "The biochemical mechanisms involved in transducing signals from the outside of a cell to the cell's interior have been the subject of countless studies. Only in recent years has it been appreciated that enzymes possessing tyrosine protein kinase activity, originally noted as the oncogenes of retroviruses, are involved in normal cell signal transduction. These facts, coupled with the significant progress made by immunologists in the identification and characterization of receptors on cells of the immune system, have led to the close scrutiny of the potential role of tyrosine protein kinases in signal transduction by hemopoietic cell surface molecules. Among receptors of this class, much attention has been focused on the surface immunoglobulin, or antigen...
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