J.J. Goedert, C.M. Kessler, L.M. Aledort, R.J. Biggar, et al., "A prospective study of human immunodeficiency virus type-1 infection and the development of AIDS in subjects with hemophilia," New England Journal of Medicine, 321:1141-48, 1989.

James J. Goedert (Viral Epidemiology Section, National Cancer Institute, Bethesda, Md.): "This paper summarizes the substantial contributions of a multidisciplinary team that has worked together for five or more years. The goal of our team has been a better understanding of HIV infection and disease, focusing on the largest cohort of patients with hemophilia reported to date. "Like the contributors, the paper has several angles. These include estimates of HIV annual incidence and prevalence; annual and cumulative AIDS incidence measured from estimated date of HIV infection; and time-dependent markers of AIDS risk, such as CD4-lymphocyte and interferon levels. Cofactors of AIDS risk are also discussed.

"We further dissected our finding of a strong association between...

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