K.S. Campbell, J.C. Cambier, "B lymphocyte antigen receptors (mlg) are non-covalently associated with a disulfide linked, inducibly phosphorylated glycoprotein complex," EMBO Journal, 9:441-48, 1990.
Kerry S. Campbell ( National Jewish Center for Immunology and Respiratory Medicine, Denver): "B cell antigen receptors are membrane-bound forms of immunoglobulin (mlg) that transduce essential growth-promoting signals. Interestingly, their cytoplasmic structure appears inadequate for direct physical coupling to intracellular signalling proteins. For nearly two decades, immunologists have searched for transducers. In the cited paper, we found that stimulation of permeabilized B cells with aluminum fluoride in the presence of 32p-ato led to efficient radiolabeling of glycoprotein heterodimers that could be immunoprecipitated with the receptor. The heterodimers have more recently been identified by other researchers as products of the previous cloned mb-1 and B29 genes. They are essential for receptor surface expression and appear to couple the receptor to the tyrosine kinase Lyn. We feel...
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