Immunology

B.R. Cullen, W.C. Greene, "Regulatory pathways governing HIV-1 replication," Cell, 58, 423-6, 11 August 1989.

Bryan R. Cullen (Duke University Medical Center, Durham, N.C.): "Human immunodeficiency virus type 1 (HIV-1) is the major viral pathogen of the present era. As such, the regulation of HIV-1 replication is of interest to a broad audience, from clinicians to molecular biologists. This is particularly true when one considers that gene regulation in HIV-1 is remarkably complex when compared to gene regulation in the murine and avian retroviruses that have served as models for the study of retroviral replication. Indeed, the two trans-acting nuclear proteins encoded by HIV-1 have mechanisms of action that are unprecedented in any other regulatory system, whether viral or cellular. A scientific consensus on the regulatory phenomena governing HIV-1 replication began to form in 1989, so that this review article was able to provide a very timely overview of the...