M.E. Hemler, "VLA proteins in the integrin family: structures, functions, and their role on leukocytes," Annual Review of Immunology, 8, 365-400, 1990.

Martin E. Hemler (Dana-Farber Cancer Institute, Boston): "The focus of this review is VLA proteins. As members of the integrin family, these proteins mediate adhesion to a variety of extracellular matrix and cell surface ligands. These receptors attract wide attention because of their involvement in diverse areas such as embryo-genesis, leukocyte migration and activation, nerve cell function, tumor metastasis, thrombosis, hemostasis, wound healing, tissue assembly, and bacterial invasion. Many of these aspects of integrins have been covered in earlier outstanding reviews. This current review may appeal to a broad audience because it attempts to give an update on integrin subunit structures, the increasing complexity of integrin subunit associations, and the many functional capabilities of the different heterodimers. Also, the immunological slant of this review touches on the role...

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