Anticancer microRNA Braids

RNAs wound together can replenish or diminish levels of miRNAs thrown into disarray by cancer.

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Ruth Williams

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Mar 31, 2016

STICKING IT TO TUMORS: To deliver therapeutic microRNAs (miRs) to tumors, braids of three microRNAs (miRs)—an antisense strand that blocks a miR overactive in cancer, a strand that replaces a deficient miR, and a stabilizing strand (1)—are added to a dendrimer (2) and mixed with a hydrogel scaffold (3). When researchers introduced the sticky gel onto mouse mammary tumors (4), the malignancies shrank and the animals lived longer (5). © GEORGE RETSECK; J.CONDE ET AL., NATURE MATERIALSRead the full article here.

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