Deciding Cell Fate

How RNA methylation helps control stem cell differentiation

and Gidi Rechavi, Dan Dominissini, and Chuan He
Dec 31, 2015

Among its many roles in the cell, m6A methylation helps regulate the expression of RNA transcripts that mediate the transition from pluripotency to differentiation. The presence of m6A appears to decrease the stability of transcripts important for maintaining pluripotency, priming the cells for future differentiation. The loss of METTL3, an m6A methlyase component, in mouse embryonic stem cells leads to the cells’ inability to exit the pluripotent state, a lethal outcome in the early embryos.

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