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Infographic: Bacterial Microcompartments Basics
Infographic: Bacterial Microcompartments Basics

Infographic: Bacterial Microcompartments Basics

These icosahedral structures are composed of proteins with unique geometric properties, which enable bacteria to employ them in a variety of situations.

Amber Dance
Amber Dance

Amber Dance is an award-winning freelance science journalist based in Southern California. After earning a doctorate in biology, she re-trained in journalism as a way to engage her broad interest...

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ABOVE: © THOM GRAVES

Many different bacterial species contain small, protein-based compartments that expand cells’ metabolic repertoires by sequestering chemical reactions. Depending on their enzyme contents, the compartments can fix carbon, break down molecules for energy, or protect cells from stressful conditions.

Components

Bacterial microcompartment shells are built out of thousands of protein subunits that fall into three basic structural motifs:

© thom graves

BMC: The principal shell protein comes in two main forms, BMC-H, which forms a hexamer, and BMC-T, which forms a trimer. These hexagon-shape components tile together to form the 20 sides of the icosahedron and have a central pore to allow substrates in and products out. The pores in the BMC-H tiles are small, allowingmolecules of just one or a few carbon atoms in and out of the microcompartment. BMC-T pores, on the other hand, are larger, presumably for movement of bigger molecules, and these...

BMV: These pentameric proteins form the vertices of the icosahedron.

Assembly

Some microcompartments form when the inner components aggregate (1) the shell proteins assemble around enzymes and other molecules (2) to generate the completed compartment (3). Other types of microcomparments form when the core proteins and shell come together at the same time (not shown).

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© thom graves


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