In cells with normal satellite DNA–binding proteins, chromocenters pull several chromosomes together.
© lucy reading-ikkanda
When the function of the DNA-binding proteins is experimentally altered, chromocenter formation also changes.
© lucy reading-ikkanda
| Elimination of satellite DNA–binding proteins | Overexpression of satellite DNA–binding proteins | Protein binding to abnormal sites |
| Chromocenters cannot form; chromosomes bleb away from the nucleus in micronuclei | Chromosomes gather in larger bunches than normal, limiting the number of chromocenters formed | All regions in contact with the DNA-binding proteins are pulled into chromocenters |
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