Infographic: Effects of Satellite DNA–Binding Proteins

The linkers gather chromosomes together into chromocenters.

Sukanya Charuchandra
Sukanya Charuchandra

Originally from Mumbai, Sukanya Charuchandra is a freelance science writer based out of wherever her travels take her. She holds master’s degrees in Science Journalism and Biotechnology. You can read...

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Oct 1, 2018

In cells with normal satellite DNA–binding proteins, chromocenters pull several chromosomes together.

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When the function of the DNA-binding proteins is experimentally altered, chromocenter formation also changes.

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Elimination of satellite DNA–binding proteins
Overexpression of satellite DNA–binding proteins
Protein binding to abnormal sites
Chromocenters cannot form; chromosomes bleb away from the nucleus in micronuclei
Chromosomes gather in larger bunches than normal, limiting the number of chromocenters formed
All regions in contact with the DNA-binding proteins are pulled into chromocenters

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