ABOVE: MODIFIED FROM
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To find out whether a particular genetic variant is present, a purified DNA sample is pipetted onto a transistor loaded with Cas9 and guide RNA. If the Cas9 complex finds its target sequence and binds to it, the transistor’s electrical current is altered, and the change is detected (plus sign) and presented on the device’s digital display.
Target variant detected
Target variant not detected
© george retseck
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