Infographic: How Fat Cells Influence Tumor Growth
Infographic: How Fat Cells Influence Tumor Growth

Infographic: How Fat Cells Influence Tumor Growth

Mice that lack p62 in their fat cells grow more tumors than animals that have a functioning version of the protein.

Apr 1, 2019
Catherine Offord

To investigate how fat cells communicate with tumors, researchers knocked out the protein p62 in adipose tissue of a mouse model of prostate cancer (1). The lack of p62 inhibited the activity of the metabolism-regulating mTORC1 complex (2) and reduced the metabolism of fats in adipose tissue (3), leaving tumor cells with more nutrients at their disposal. p62 deficiency also triggered the secretion of osteopontin (OPN), (4) a protein that promotes tumor proliferation and invasion (5).

© Ikumi Kayama, Studio Kayama

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