Infographic: Examining Open Chromatin

See how researchers visualize regions of active genes.

ruth williams
Ruth Williams

Ruth is a freelance journalist.

View full profile.


Learn about our editorial policies.

Dec 31, 2016

© GEORGE RETSECK; XINGQI CHEN, STANFORD UNIVERSITY

ATAC DO

The next generation of a technique called ATAC-seq, which captures and sequences active regions of DNA (1), allows for the visualization of these regions as well. In ATAC-see, a so-called transposome (2) uses a transposase enzyme (yellow) to insert a pair of fluorescent DNA tags into open regions of chromatin (3). Upon insertion, the DNA is cleaved (4) and the tags are visible under a microscope (5) human cells’ open chromatin labeled red). These tagged sections of DNA are then sequenced.

Read the full story.

Interested in reading more?

Infographic: Examining Open Chromatin

The Scientist ARCHIVES

Become a Member of

Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?