Infographic: Exosomes and Insulin Resistance

Circulating microRNAs may help explain how excess fat can lead to insulin resistance in distant cells.

cofford
Catherine Offord

Catherine is a senior editor at The Scientist.

View full profile.


Learn about our editorial policies.

Nov 30, 2017

© LAURIE O'KEEFE

Obesity promotes insulin resistance via exosomal microRNAs, according to researchers at the University of California, San Diego. Macrophages associated with adipocytes in mouse fatty tissue package microRNAs into exosomes, which are released into circulation and are taken up by other cell types. When researchers treated lean mice with exosomes made by macrophages from obese mice, they found that despite remaining lean, recipient mice became insulin resistant. In contrast, treating obese mice with exosomes from lean mice improved the recipient animals’ insulin sensitivity, without reducing their weight.

Read the full story.

Interested in reading more?

Infographic: Exosomes and Insulin Resistance

The Scientist ARCHIVES

Become a Member of

Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?