Infographic: How Escaped Chromosomes Can Aid Metastasis

Errors in segregation during cell division can lead to inflammation in daughter cells.

Jim Daley
Mar 31, 2018

When a chromosomally unstable cell divides, its chromosomes can become disordered during anaphase (1). Errors in segregation can allow chromosomes to leak into the cytosol, where they form “micronuclei” (2), which trigger an inflammatory response in the daughter cell (3). This response can lead to metastasis.

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