ADVERTISEMENT
ADVERTISEMENT
Infographic: How Macrophage Mitochondria Help Destroy Pathogens
Infographic: How Macrophage Mitochondria Help Destroy Pathogens

Infographic: How Macrophage Mitochondria Help Destroy Pathogens

Researchers have uncovered a mechanism whereby macrophages employ their energy-generating organelles to aid in bacterial killing.

katya katarina zimmer
Katarina Zimmer

After a year teaching an algorithm to differentiate between the echolocation calls of different bat species, Katarina decided she was simply too greedy to focus on one field. Following an internship with The Scientist in 2017, she has been happily freelancing for a number of publications, covering everything from climate change to oncology.

View full profile.


Learn about our editorial policies.

ABOVE: © istock.COM, wir0man

When a macrophage engulfs a bacterium, it triggers a stress pathway in the endoplasmic reticulum (1). This in turn stimulates mitochondria to produce reactive oxygen species (2), which are packaged into vesicles and shuttled to the phagosome (3). There, the damaging molecules are thought to aid in killing the pathogen. Finally, the bacterial remains are degraded once the phagosome fuses with a lysosome (4).

© Steve Graepel

Read the full story.

Interested in reading more?

Magaizne Cover

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?
ADVERTISEMENT