Infographic: How Macrophage Mitochondria Help Destroy Pathogens
Infographic: How Macrophage Mitochondria Help Destroy Pathogens

Infographic: How Macrophage Mitochondria Help Destroy Pathogens

Researchers have uncovered a mechanism whereby macrophages employ their energy-generating organelles to aid in bacterial killing.

Jan 1, 2019
Katarina Zimmer

ABOVE: © istock.COM, wir0man

When a macrophage engulfs a bacterium, it triggers a stress pathway in the endoplasmic reticulum (1). This in turn stimulates mitochondria to produce reactive oxygen species (2), which are packaged into vesicles and shuttled to the phagosome (3). There, the damaging molecules are thought to aid in killing the pathogen. Finally, the bacterial remains are degraded once the phagosome fuses with a lysosome (4).

© Steve Graepel

Read the full story.